Diagnostic Value of Chitinase-3-like Protein 1 and Keratin 5 in Bronchoalveolar Lavage Fluid of Lung Cancer

To investigate the diagnostic value of chitinase-3-like protein 1 and keratin 5 in bronchoalveolar lavage fluid 88 patients with lung disease. This was a case control study to collect 50 cancer (malignant disease group) 38 benign (benign who were admitted respiratory medicine department affiliated hospital medical school Ningbo university from December 2019 March 2020. The enzyme-linked immunosorbent assay applied detect expression levels two groups patients. effect evaluated using subject's working characteristics establish mathematical model. significantly higher malignant group than (p<0.05). These (chitinase-3-like 5) correlated positively combined test could improve sensitivity specificity diagnosis. rate for cancer. carcinoembryonic antigen blood superior chitinase-3- like or alone diagnosis Chitinase-3-like contribute early can be used as biomarkers high specificity. application assays molecular markers clinical targeted therapeutic agents needs further studied.